This generates two separate monovalent ( containing a single antibody binding site ) Fab fragments and an intact Fc fragment.
3.
The Fc fragment of the IgG antibody, for example, is a homodimer with a highly conserved N-glycosylation site.
4.
It was determined that the two antigen binding sites of the antibody are located opposite the Fc fragment, the part of the antibody responsible for binding to receptor cells.
5.
Antibody genes also re-organize in a process called class switching that changes the one type of heavy chain Fc fragment to another, creating a different isotype of the antibody that retains the antigen-specific variable region.
6.
The patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts ( papain is used to cleave the antibody into Fab and Fc fragments ) should not use ovine digoxin immune fab.
7.
"' Belatacept "'( trade name "'Nulojix "') is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4, which is a molecule crucial in the regulation of T-cell costimulation, selectively blocking the process of T-cell activation.
8.
"' Figure 5 "': Chemical glycosylation of the IgG Fc fragment ( Chain A and B ) the glycosyltion site "'A "') Formylglycine-generating enzyme ( FGE ) oxidizes the cysteine residue to an aldehyde function "'B "') Aminooxy-N-Acetylglucoseamine ( AO-GlcNAc ) is coupled to Fc via oxime formation "'C "') GlcNAc is further elongated by different carbohydrate moieties with the help of the endoglycosidase EndoS ( EndoS-D233Q)
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